The first release of oro.nifti (v0.1.3) is a bundle of functions and capabilities from dcemriS4. This package is able to read/write both NIfTI and Analyze data formats for medical imaging. S4 classes are available and numerous methods exist to visualize and interact with these data formats. NIfTI extensions are allowed both as input and output. With the XML package installed there is the ability to keep an "audit trail" of all operations that have been applied to a particular S4 data object.